Synthesis and antitumor evaluation of thiophene based azo dyes incorporating pyrazolone moiety
نویسندگان
چکیده
منابع مشابه
Thiophene-Based Azo Dyes and Their Applications in Dyes Chemistry
The thiophene-based azo dyes class of azo dyes have generated considerable interest since its discovery 62 years ago. These dyes have come to be applied to a very large number and variety of fibres and have therefore achieved an importance which is probably greater than the weights used would suggest. The connection between dyeing and fastness properties on the one hand and chemical constitutio...
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New cyclohepta[b]thiophene analogs were designed and synthesized. Compounds 2-4, 6 and 8a-c were assessed for in vitro antitumor efficacy toward breast cancer (MCF-7), hepatocyte (HepG2) and colon adenocarcinoma (HT-29) cell lines. Compound 6 showed the highest efficacy toward the three tested cell lines. In vivo antitumor efficacy of compounds 2, 6 and 8a,b toward Ehrlich ascites carcinoma (EA...
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متن کاملSynthesis and Characterization of Some New Bis-Pyrazolyl-Thiazoles Incorporating the Thiophene Moiety as Potent Anti-Tumor Agents
A new series of 1,4-bis(1-(5-(aryldiazenyl)thiazol-2-yl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-3-yl)benzenes 3a-i were synthesized via reaction of 5,5'-(1,4-phenylene)bis(3-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide) (1) with hydrazonoyl halides 2a-i. In addition, reaction of 1 with ethyl chloroacetate afforded bis-thiazolone derivative 8 as the end product. Reaction of compoun...
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ژورنال
عنوان ژورنال: Journal of Saudi Chemical Society
سال: 2016
ISSN: 1319-6103
DOI: 10.1016/j.jscs.2012.06.004